Ctgf sirna
WebMar 2, 2004 · Abstract. Connective tissue growth factor (CTGF/CCN2), a cysteine-rich protein of the CCN (Cyr61, CTGF, Nov) family of genes, emerged from a microarray screen of genes expressed by human rhabdomyosarcoma cells. Rhabdomyosarcoma is a soft tissue sarcoma of childhood deriving from skeletal muscle cells. In this study, we …
Ctgf sirna
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WebDownload scientific diagram CTGF regulates collagen in HEK293-MAS cells treated with MAS agonist (AR234960). MAS expressing HEK293 cells were transiently transfected with control siRNA and CTGF ... WebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. It was first isolated in 1991 from serum-stimulated NIH3T3 cells and named fisp12 (fibroblast-inducible secreted protein-12). The term ‘connective tissue growth factor ...
WebOverexpression of CTGF enhances resistance to 5-FU-promoting cell death. To examine the potential role of CTGF on the regulation of chemoresistance to 5-FU, we first confirmed that the pCDNA3.1-CTGF vector and CTGF small interfering RNA (CTGF-siRNA) were overexpressing and interfering with the protein and mRNA of CTGF in HT-29 and SW620 … WebMar 10, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes. ... we transfected Glut1 siRNA to ...
WebNational Center for Biotechnology Information WebDec 9, 2024 · Transfection of Small Interfering RNA. The mRNA sequences of rat CTGF (NM_022266) were acquired from NCBI GenBank. Small interfering RNA (siRNA) against rat CTGF was designed and synthesized by GenePharma Biological Company (Shanghai, China).
WebPushing through the pipeline OLX101, which targets the connective tissue growth factor (CTGF) gene, is OliX’s most advanced program, and is in clinical development as an …
WebBackground: Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to … cinnaholic rollsWebJul 1, 2011 · Transgenic mice that over-express connective tissue growth factor (CTGF) in fibroblasts under the control of an enhancer/promoter element of the Col1a2 gene (Col1a2-CTGF) ... and were transfected with Sparc siRNA or Ctgf siRNA. Real-time quantitative RT-PCR and Western blotting were used to examine the transcription and … cinnaholic richardson txWebJan 29, 2024 · However, only CTGF siRNA knockdown, could compromise TGFβ1-induced collagen expression. Finally, the immunohistochemistry revealed vimentin- and α-SMA-positive staining for (myo)fibroblasts, TGFβ1, collagen, and CTGF in the subepithelial stroma region of human adenomyotic endometria. diagnostics immobiliers hemWeb现就近年来siRNA在肝纤维化治疗中的应用进行综述如下。 1 siRNA的结构及特点. siRNA由Dicer(RNAase Ⅲ家族中对dsRNA有特异性的酶)加工而成，其长度为20～25个核苷酸。作为非编码RNA家族中的一员，siRNA具有两条链，分别为正义链、反义链。 cinnaholic reviewsWebFeb 1, 2024 · Additionally, SREBP1-overexpressing 8505C and K1 cells were transfected with control siRNA or siRNA targeting CYR61 or CTGF. CYR61 or CTGF silencing mitigated SREBP1-facilitated invasiveness . Taken together, the promotion of invasive phenotypes by SREBP1 was, at least in part, mediated by CYR61/CTGF via the Hippo … diagnostic significance of amylaseWebCTGF siRNA と shRNA プラスミド (h) CTGFsiRNA(h)、shRNAとレンチウイルス粒子遺伝子サイレンサー は、 1 件のレビューによって、 5 つ星のうち 4.0 と 評価されています。 diagnostics_image-original_hashWebsiRNA products generally consist of pools of three to five target-specific 19-25 nt siRNAs designed to knockdown gene expression; for independent verification of CTGF gene … cinnaholic richardson